Authors: Benjamin Roche, Beata Ujvari & Frédéric Thomas

Source: Evolutionary Applications (21 February 2018)

Brief summary of the paper: Many biological systems are resilient to shock and have the ability to return to a previous state following a disturbance. In the case of cancer, this resilience may jeopardize our understanding of tumerous cell proliferation and presents many clinical problems, including therapeutic resistance.

Indeed, during progression and treatment, cancer has the capacity to exhibit resistance, resilience, and robustness, making its dynamics very challenging to forecast. Furthermore, organisms have evolved defenses that increase the robustness to mutations and other perturbations that can increase cancer susceptibility.